Grayanotoxins, whether consumed in mad honey or in any Element of the rhododendron, get the job done from the human physique by binding to voltage-gated sodium ion channels in cells. This retains the channels from closing speedily, describes forensic toxicologist Justin Brower in his blog site,
To this point, it's best to examine using your state or local federal government before stocking up on jars of mad honey. And Keep in mind, eat mad honey responsibly!
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“Grayanotoxins exert their toxicity by binding to sodium ion channels on cell membranes and stopping them from closing rapidly, like aconitine. The end result is actually a condition of depolarization wherein sodium ions are freely flowing in the cells, and calcium influx is on the rise.”
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